Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/106161
Title: Molecular geometry and physicochemical characteristics of selected anilinoquinolines, indolo[3,2-c]quinolines and tetrahydroindolo[3,2- d]benzazepines
Authors: Koh, H.-L. 
Go, M.-L. 
Ngiam, T.-L. 
Issue Date: 1994
Source: Koh, H.-L.,Go, M.-L.,Ngiam, T.-L. (1994). Molecular geometry and physicochemical characteristics of selected anilinoquinolines, indolo[3,2-c]quinolines and tetrahydroindolo[3,2- d]benzazepines. Chemical and Pharmaceutical Bulletin 42 (5) : 1084-1087. ScholarBank@NUS Repository.
Abstract: The molecular geometry, acid dissociation constants and partition coefficients of the anilinoquinoline (I), indolo[3,2-c]quinoline (II) and tetrahydroindolo[3,2-d] [1]benzazepine (III) ring systems have been determined using representative compounds: 7-chloro-4-(p-anisidino)quinoline (Ia), 3-chloro-8-methoxy-11H-indolo[3,2-c]-quinoline (IIa) and 3-chloro-9- methoxy-5,6,7,12-tetrahydroindolo[3,2-d] [1]benzazepine (IIIa). Ring systems II and III are cyclic analogues of I. The minimum energy conformation was determined by molecular mechanics. Compound IIa is the most planar and conformationally restricted, followed by IIIa and Ia. The acid dissociation constants (pK(a)) were determined by the solubility method. The ring nitrogen of Ia is most basic, followed by that of IIa and IIIa. The partition coefficient (log P) was determined between octanol and appropriate aqueous buffers by the shaken flask method. Hydrophobicity decreases in the order of Ia > IIa > IIIa. Factors contributing to the different molecular geometry, pK(a) and hydrophobicity of these related compounds are discussed. The present study may contribute to the design of better drugs with ring system I, II or III.
Source Title: Chemical and Pharmaceutical Bulletin
URI: http://scholarbank.nus.edu.sg/handle/10635/106161
ISSN: 00092363
Appears in Collections:Staff Publications

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