Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/106122
Title: Matrix swelling: A simple model describing extent of swelling of HPMC matrices
Authors: Sai Cheong Wan, L. 
Wan Sia Heng, P. 
Fun Wong, L.
Keywords: Case I diffusion
Case II model
Case II relaxation
Coupled Case I
Hydroxypropylmethylcellulose
Swelling
Viscosity
Issue Date: 28-Mar-1995
Citation: Sai Cheong Wan, L.,Wan Sia Heng, P.,Fun Wong, L. (1995-03-28). Matrix swelling: A simple model describing extent of swelling of HPMC matrices. International Journal of Pharmaceutics 116 (2) : 159-168. ScholarBank@NUS Repository.
Abstract: The swelling of HPMC matrices was measured by determining the vertical displacement with time using a dial indicator. Curve fitting of the data of swelling was carried out by using the coupled Case I-Case II model. The thickness of the swollen layer formed around the matrix core was greater in HPMC compacts of higher viscosity grade. The rates of Case I (αs coefficient) and Case II (βs coefficient) swelling mechanisms increased with concentration and/or viscosity grade of HPMC. © 1995.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/106122
ISSN: 03785173
Appears in Collections:Staff Publications

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