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|Title:||Matrix swelling: A simple model describing extent of swelling of HPMC matrices|
|Authors:||Sai Cheong Wan, L. |
Wan Sia Heng, P.
Fun Wong, L.
|Keywords:||Case I diffusion|
Case II model
Case II relaxation
Coupled Case I
|Citation:||Sai Cheong Wan, L.,Wan Sia Heng, P.,Fun Wong, L. (1995-03-28). Matrix swelling: A simple model describing extent of swelling of HPMC matrices. International Journal of Pharmaceutics 116 (2) : 159-168. ScholarBank@NUS Repository.|
|Abstract:||The swelling of HPMC matrices was measured by determining the vertical displacement with time using a dial indicator. Curve fitting of the data of swelling was carried out by using the coupled Case I-Case II model. The thickness of the swollen layer formed around the matrix core was greater in HPMC compacts of higher viscosity grade. The rates of Case I (αs coefficient) and Case II (βs coefficient) swelling mechanisms increased with concentration and/or viscosity grade of HPMC. © 1995.|
|Source Title:||International Journal of Pharmaceutics|
|Appears in Collections:||Staff Publications|
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