Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/106116
Title: Liquid penetration into matrices
Authors: Wan, L.S.C. 
Heng, P.W.S. 
Wong, L.F.
Keywords: Case I diffusion
Case II relaxation
coupled Case I/Case II model
hydroxypropylmethylcellulose
liquid penetration
viscosity
Washburn equation
Issue Date: 1993
Source: Wan, L.S.C.,Heng, P.W.S.,Wong, L.F. (1993). Liquid penetration into matrices. S.T.P. Pharma Sciences 3 (6) : 477-487. ScholarBank@NUS Repository.
Abstract: Liquid penetration profiles of hydroxypropylmethylcellulose (HPMC)/drug matrices were studied using propranolol hydrochloride and ibuprofen as model drugs. The kinetics of liquid uptake into these matrices was fitted with different kinetic models. The classical Washburn equation failed to describe fully the liquid penetration into a matrix system compressed with a swelling polymer. A polynomial equation incorporating both Fickian Case I diffusion and Case II relaxational models was found to be more appropriate in these cases. The α-coefficient (Case I component) of HPMC/drug matrices increased with polymer concentration. On the other hand, the β-coeffcient (Case II component) remained relatively unchanged when the polymer content was varied. An increase in the polymer content of HPMC/drug matrices shifts the ratio of the two contributions towards an increase in Case I and a decrease in Case II contributions to overall uptake.
Source Title: S.T.P. Pharma Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/106116
ISSN: 11571489
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

21
checked on Feb 17, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.