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Title: Liquid penetration into matrices
Authors: Wan, L.S.C. 
Heng, P.W.S. 
Wong, L.F.
Keywords: Case I diffusion
Case II relaxation
coupled Case I/Case II model
liquid penetration
Washburn equation
Issue Date: 1993
Citation: Wan, L.S.C.,Heng, P.W.S.,Wong, L.F. (1993). Liquid penetration into matrices. S.T.P. Pharma Sciences 3 (6) : 477-487. ScholarBank@NUS Repository.
Abstract: Liquid penetration profiles of hydroxypropylmethylcellulose (HPMC)/drug matrices were studied using propranolol hydrochloride and ibuprofen as model drugs. The kinetics of liquid uptake into these matrices was fitted with different kinetic models. The classical Washburn equation failed to describe fully the liquid penetration into a matrix system compressed with a swelling polymer. A polynomial equation incorporating both Fickian Case I diffusion and Case II relaxational models was found to be more appropriate in these cases. The α-coefficient (Case I component) of HPMC/drug matrices increased with polymer concentration. On the other hand, the β-coeffcient (Case II component) remained relatively unchanged when the polymer content was varied. An increase in the polymer content of HPMC/drug matrices shifts the ratio of the two contributions towards an increase in Case I and a decrease in Case II contributions to overall uptake.
Source Title: S.T.P. Pharma Sciences
ISSN: 11571489
Appears in Collections:Staff Publications

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