Please use this identifier to cite or link to this item: https://doi.org/10.1365/s10337-010-1727-2
Title: LC Determination of trans-3,5,3′,4′,5′- pentamethoxystilbene in rat plasma
Authors: Lin, H.-S. 
Tringali, C.
Spatafora, C.
Choo, Q.-Y.
Ho, P.C. 
Keywords: Column liquid chromatography
Oral bioavailability
Pharmacokinetic study
Resveratrol analog
trans-3,5,3′,4′,5′-Pentamethoxystilbene
Issue Date: Nov-2010
Citation: Lin, H.-S., Tringali, C., Spatafora, C., Choo, Q.-Y., Ho, P.C. (2010-11). LC Determination of trans-3,5,3′,4′,5′- pentamethoxystilbene in rat plasma. Chromatographia 72 (9-10) : 827-832. ScholarBank@NUS Repository. https://doi.org/10.1365/s10337-010-1727-2
Abstract: A simple LC method has been developed and validated to determine trans-3,5,3′,4′,5′-pentamethoxystilbene (PMS) in rat plasma. Chromatographic separation was achieved through gradient delivery of acetonitrile and water (1.5 mL min-1) at 50 °C. PMS was quantified using UV detection at 320 nm. The standard curve ranged from 15 to 1,500 ng mL-1. The intra- and inter-day precisions, in terms of CV, were all less than 10% while the inter-day and intra-day bias ranged from -6.8 to 8.3%. The plasma PMS levels were monitored in Sprague-Dawley rats after drug administration. This simple LC method appears to be useful in the pharmacokinetic investigation of PMS. © 2010 Vieweg+Teubner Verlag | Springer Fachmedien Wiesbaden GmbH.
Source Title: Chromatographia
URI: http://scholarbank.nus.edu.sg/handle/10635/106108
ISSN: 00095893
DOI: 10.1365/s10337-010-1727-2
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