Please use this identifier to cite or link to this item:
|Title:||Kinetic study of a 2-hydroxypropyl-β-cyclodextrin-based formulation of all-trans-retinoic acid in Sprague-Dawley rats after oral or intravenous administration|
|Authors:||Lin, H.-S. |
|Source:||Lin, H.-S.,Chan, S.Y.,Low, K.S.Y.,Shoon, M.L.,Ho, P.C. (2000-02). Kinetic study of a 2-hydroxypropyl-β-cyclodextrin-based formulation of all-trans-retinoic acid in Sprague-Dawley rats after oral or intravenous administration. Journal of Pharmaceutical Sciences 89 (2) : 260-267. ScholarBank@NUS Repository. https://doi.org/10.1002/(SICI)1520-6017(200002)89:23.0.CO;2-Q|
|Abstract:||all-trans-Retinoic acid (ATRA, vitamin A acid, or tretinoin) is a potent chemotherapeutic agent for the treatment of acute promyelocytic leukemia (APL). Its poor aqueous solubility not only affects its oral absorption but also prevents it from forming an aqueous parenteral formulation. Recently, we developed a water-soluble formulation of ATRA with 2-hydroxypropyl-β- cyclodextrin (HPβCD). In present study, this formulation was tested in Sprague-Dawley rats. Kinetic study of ATRA was carried out after oral or intravenous administration. Though there were no statistical differences in any of the estimated pharmacokinetic parameters between ATRA sodium salt and HPβCD-based ATRA after intravenous administration, inclusion of ATRA into HPβCD was found to greatly improve the oral absorption of ATRA. (C) 2000 Wiley-Liss Inc.|
|Source Title:||Journal of Pharmaceutical Sciences|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 13, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.