Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jpba.2008.01.016
Title: Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements
Authors: Zou, P.
Hou, P.
Oh, S.S.-Y.
Chong, Y.M.
Bloodworth, B.C.
Low, M.-Y.
Koh, H.-L. 
Keywords: Adulterant
Health supplement
PDE-5 inhibitor
Thiohomosildenafil
Thiosildenafil
Issue Date: 9-Jun-2008
Source: Zou, P., Hou, P., Oh, S.S.-Y., Chong, Y.M., Bloodworth, B.C., Low, M.-Y., Koh, H.-L. (2008-06-09). Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements. Journal of Pharmaceutical and Biomedical Analysis 47 (2) : 279-284. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jpba.2008.01.016
Abstract: Two unknown compounds are detected and isolated from health supplements for the enhancement of sexual function. The structures of the unknown compounds are elucidated using high-resolution MS, ESI-MS/MS, NMR, UV and IR. One compound is identified as an analogue of sildenafil in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety, and an ethyl group instead of a methyl group is attached to the piperazinyl nitrogen. Hence, this compound is named thiohomosildenafil. Another compound is also a sildenafil analogue in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety. This compound is named thiosildenafil. Both the two compounds are first detected in health supplements. The UV, IR and completely assigned NMR data of thiohomosildenafil and thiosildenafil are first reported. © 2008 Elsevier B.V. All rights reserved.
Source Title: Journal of Pharmaceutical and Biomedical Analysis
URI: http://scholarbank.nus.edu.sg/handle/10635/106097
ISSN: 07317085
DOI: 10.1016/j.jpba.2008.01.016
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