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|Title:||Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements|
|Citation:||Zou, P., Hou, P., Oh, S.S.-Y., Chong, Y.M., Bloodworth, B.C., Low, M.-Y., Koh, H.-L. (2008-06-09). Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements. Journal of Pharmaceutical and Biomedical Analysis 47 (2) : 279-284. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jpba.2008.01.016|
|Abstract:||Two unknown compounds are detected and isolated from health supplements for the enhancement of sexual function. The structures of the unknown compounds are elucidated using high-resolution MS, ESI-MS/MS, NMR, UV and IR. One compound is identified as an analogue of sildenafil in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety, and an ethyl group instead of a methyl group is attached to the piperazinyl nitrogen. Hence, this compound is named thiohomosildenafil. Another compound is also a sildenafil analogue in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety. This compound is named thiosildenafil. Both the two compounds are first detected in health supplements. The UV, IR and completely assigned NMR data of thiohomosildenafil and thiosildenafil are first reported. © 2008 Elsevier B.V. All rights reserved.|
|Source Title:||Journal of Pharmaceutical and Biomedical Analysis|
|Appears in Collections:||Staff Publications|
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