Please use this identifier to cite or link to this item:
|Title:||Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements|
|Citation:||Zou, P., Hou, P., Oh, S.S.-Y., Chong, Y.M., Bloodworth, B.C., Low, M.-Y., Koh, H.-L. (2008-06-09). Isolation and identification of thiohomosildenafil and thiosildenafil in health supplements. Journal of Pharmaceutical and Biomedical Analysis 47 (2) : 279-284. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jpba.2008.01.016|
|Abstract:||Two unknown compounds are detected and isolated from health supplements for the enhancement of sexual function. The structures of the unknown compounds are elucidated using high-resolution MS, ESI-MS/MS, NMR, UV and IR. One compound is identified as an analogue of sildenafil in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety, and an ethyl group instead of a methyl group is attached to the piperazinyl nitrogen. Hence, this compound is named thiohomosildenafil. Another compound is also a sildenafil analogue in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety. This compound is named thiosildenafil. Both the two compounds are first detected in health supplements. The UV, IR and completely assigned NMR data of thiohomosildenafil and thiosildenafil are first reported. © 2008 Elsevier B.V. All rights reserved.|
|Source Title:||Journal of Pharmaceutical and Biomedical Analysis|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 6, 2018
WEB OF SCIENCETM
checked on Oct 22, 2018
checked on Oct 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.