Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jpba.2012.07.008
Title: Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements
Authors: Kee, C.-L.
Ge, X.
Koh, H.-L. 
Low, M.-Y.
Keywords: Health supplement
MS
NMR
Propoxyphenyl aildenafil
Propoxyphenyl thioaildenafil
Issue Date: Nov-2012
Citation: Kee, C.-L., Ge, X., Koh, H.-L., Low, M.-Y. (2012-11). Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements. Journal of Pharmaceutical and Biomedical Analysis 70 : 265-272. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jpba.2012.07.008
Abstract: Two new phosphodiesterase-5 inhibitors (PDE-5) which consist of one sildenafil analogue and one thiosildenafil analogue have been found in heath supplements. The structural properties of these analogues have been elucidated by NMR, high resolution MS, MS2, UV and IR spectroscopy. The sildenafil analogue is very similar to aildenafil and the thiosildenafil analogue is similar to thioaildenafil, except the ethoxy group bonded to phenyl ring is replaced by a propoxy group. Hence, the sildenafil analogue is named as propoxyphenyl aildenafil or propoxyphenyl methisosildenafil and the thiosildenafil analogue as propoxyphenyl thioaildenafil or propoxyphenyl thiomethisosildenafil. © 2012 Elsevier B.V.
Source Title: Journal of Pharmaceutical and Biomedical Analysis
URI: http://scholarbank.nus.edu.sg/handle/10635/106095
ISSN: 07317085
DOI: 10.1016/j.jpba.2012.07.008
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

23
checked on Dec 12, 2018

WEB OF SCIENCETM
Citations

19
checked on Dec 5, 2018

Page view(s)

33
checked on Sep 21, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.