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https://doi.org/10.3109/10837450.2011.621210
DC Field | Value | |
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dc.title | Insights into the functionality of pelletization aid in pelletization by extrusion-spheronization | |
dc.contributor.author | Sarkar, S. | |
dc.contributor.author | Heng, P.W.S. | |
dc.contributor.author | Liew, C.V. | |
dc.date.accessioned | 2014-10-29T01:54:29Z | |
dc.date.available | 2014-10-29T01:54:29Z | |
dc.date.issued | 2013-02 | |
dc.identifier.citation | Sarkar, S., Heng, P.W.S., Liew, C.V. (2013-02). Insights into the functionality of pelletization aid in pelletization by extrusion-spheronization. Pharmaceutical Development and Technology 18 (1) : 61-72. ScholarBank@NUS Repository. https://doi.org/10.3109/10837450.2011.621210 | |
dc.identifier.issn | 10837450 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/106067 | |
dc.description.abstract | This study investigated the particle sizes of pelletization aids from the different wet processing steps of extrusion-spheronization, and their influence on rheological and pellet properties. Three commercial microcrystalline cellulose (MCC) grades, three commercial cross-linked polyvinyl pyrrolidone (X-PVP) grades and two agglomerated X-PVP grades (prepared using roller compaction from two commercial fine particle size X-PVP grades) were used as pelletization aid. The pelletization aids were analyzed for their dry state particle size, individual particle size (sonicated powder dispersion in water) and in-process particle sizes (dispersions of processed materials from the different processing steps). No remarkable particle size changes were observed with the commercial X-PVP grades under the different conditions. The two fine X-PVP grades, but not the coarse grade, produced good quality pellets. MCC and agglomerated X-PVP grades exhibited spectacularly lower individual and in-process particle sizes, and produced good quality pellets although some of them had dry state particle sizes comparable to that of the commercial coarse X-PVP grade. In-process particle sizes of pelletization aids correlated strongly with the rheological and pellet properties of the pelletization aid:lactose (1:3) binary mixtures. These results demonstrated that small in-process particle size of pelletization aid is a critical requirement for successful pelletization by extrusion-spheronization. © 2013 Informa Healthcare USA, Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3109/10837450.2011.621210 | |
dc.source | Scopus | |
dc.subject | Cross-linked polyvinyl pyrrolidone | |
dc.subject | In-process particle | |
dc.subject | Individual particle | |
dc.subject | Microcrystalline cellulose | |
dc.type | Article | |
dc.contributor.department | PHARMACY | |
dc.description.doi | 10.3109/10837450.2011.621210 | |
dc.description.sourcetitle | Pharmaceutical Development and Technology | |
dc.description.volume | 18 | |
dc.description.issue | 1 | |
dc.description.page | 61-72 | |
dc.description.coden | PDTEF | |
dc.identifier.isiut | 000312008200008 | |
Appears in Collections: | Staff Publications |
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