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Title: Influence of hydrophile-lipophile balance on alginate microspheres
Authors: Wan, L.S.C. 
Heng, P.W.S. 
Chan, L.W. 
Keywords: Alginate microsphere
Drug release
Emulsification method
Size distribution
Issue Date: 30-Jun-1993
Citation: Wan, L.S.C.,Heng, P.W.S.,Chan, L.W. (1993-06-30). Influence of hydrophile-lipophile balance on alginate microspheres. International Journal of Pharmaceutics 95 (1-3) : 77-83. ScholarBank@NUS Repository.
Abstract: In this study, calcium alginate microspheres were prepared by an emulsification method using surfactants. A blend of sorbitan trioleate and polyoxyethylene sorbitan trioleate of varying HLB was used to produce the microspheres. The results obtained showed that the surfactant concentration and HLB played an important role in the formation of the microspheres. The size, size distribution and to a certain extent the shape were significantly affected by the HLB. However, HLB did not alter the drug encapsulation efficiency appreciably but did affect the rate of drug release. © 1993.
Source Title: International Journal of Pharmaceutics
ISSN: 03785173
Appears in Collections:Staff Publications

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