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Title: Incorporation and distribution of a low dose drug in granules
Authors: Wan, L.S.C. 
Heng, P.W.S. 
Muhuri, G.
Keywords: Chlorpheniramine maleate
Fluidised bed granulation
Low dose drug distribution
Issue Date: 8-Dec-1992
Citation: Wan, L.S.C.,Heng, P.W.S.,Muhuri, G. (1992-12-08). Incorporation and distribution of a low dose drug in granules. International Journal of Pharmaceutics 88 (1-3) : 159-163. ScholarBank@NUS Repository.
Abstract: The mixing technique of a low dose active ingredient with the bulk material is very important in pharmaceutical preparations. In the present work, manual pregranulation mixing and pregranulation mixing with a double-cone mixer were carried out. The efficiency of pregranulation mixing followed by fluidised bed granulation was compared with the technique of drug distribution through the granulating liquid. Drug was dissolved with different volumes of PVP solution and water for distribution in bulk material. The mixing of the drug particles with the bulk material by both pregranulation manual mixing and using a double-cone mixer did not achieve satisfactory drug distribution. Mixing efficiency was found to improve with an increase in the proportion of the granulating liquid used to distribute the drug. It was also found that optimum atomizing pressure is necessary for promoting uniform mixing. © 1992.
Source Title: International Journal of Pharmaceutics
ISSN: 03785173
Appears in Collections:Staff Publications

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