Please use this identifier to cite or link to this item: https://doi.org/10.1208/s12249-013-0022-6
Title: Importance of wet packability of component particles in pellet formation
Authors: Sarkar, S.
Wong, T.W.
Liew, C.V. 
Keywords: cross-linked polyvinyl pyrrolidone
extrusion
packing
spheronization
Issue Date: Sep-2013
Source: Sarkar, S., Wong, T.W., Liew, C.V. (2013-09). Importance of wet packability of component particles in pellet formation. AAPS PharmSciTech 14 (3) : 1267-1277. ScholarBank@NUS Repository. https://doi.org/10.1208/s12249-013-0022-6
Abstract: This work explored the importance of packability of component particles in the different wet processing steps of extrusion-spheronization and investigated different processing and formulation approaches for enhancing packing of component particles during extrusion-spheronization to produce spherical pellets with high yield and narrow size distribution. Various cross-linked polyvinyl pyrrolidone (XPVP) and lactose grades with different particle sizes were used as pelletization aid and filler in 1:3 binary powder blends. Loosely packed extrudates obtained from coarse XPVP/lactose blends possessed low cohesive strength and produced irregular shaped pellets with low yield whereas tightly packed, rigid extrudates obtained from XPVP/fine lactose grades possessed high cohesive strength and produced elongated pellets. Adjustment of spheronization tip speed to provide sufficient forces generated by the rotating frictional base plate for facilitating packing by rearrangement of component particles improved pellet quality. Double extrusion, decreasing particle size of the formulation component(s), and/or widening particle size distribution of the powder blend are approaches applicable to improve cohesiveness of moistened mass by closer packing of component particles for production of good quality pellets. © 2013 American Association of Pharmaceutical Scientists.
Source Title: AAPS PharmSciTech
URI: http://scholarbank.nus.edu.sg/handle/10635/106028
ISSN: 15309932
DOI: 10.1208/s12249-013-0022-6
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

5
checked on Feb 15, 2018

WEB OF SCIENCETM
Citations

5
checked on Jan 29, 2018

Page view(s)

28
checked on Feb 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.