Please use this identifier to cite or link to this item: https://doi.org/10.1080/10837450701369311
Title: Impact of a non-meltable additive on melt agglomeration with a hydrophobic meltable binder in high-shear mixer
Authors: Cheong, W.S.
Heng, P.W.S. 
Wong, T.W.
Keywords: Frictional forces
Melt agglomeration
Non-meltable additive
Surface tension
Issue Date: Jul-2007
Citation: Cheong, W.S., Heng, P.W.S., Wong, T.W. (2007-07). Impact of a non-meltable additive on melt agglomeration with a hydrophobic meltable binder in high-shear mixer. Pharmaceutical Development and Technology 12 (4) : 371-380. ScholarBank@NUS Repository. https://doi.org/10.1080/10837450701369311
Abstract: The present study aims to investigate the behavior of melt agglomeration with a low-viscosity hydrophobic meltable binder by using a non-meltable additive. The size, crushing strength, and pore size distribution of resultant agglomerates, the rheological, surface tension, and wetting properties of the molten binder, as well as, the flow characteristics of preagglomeration powder blend were determined. The use of additive showed contradictory agglomerate growth-promoting and -retarding effects on the molten binder surface tension and the interparticulate frictional forces. Critical concentration effects of additive corresponded to threshold transition of agglomeration-promoting to -retarding behavior were discussed. Copyright © Informa Healthcare USA, Inc.
Source Title: Pharmaceutical Development and Technology
URI: http://scholarbank.nus.edu.sg/handle/10635/106021
ISSN: 10837450
DOI: 10.1080/10837450701369311
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

31
checked on Jun 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.