Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jpba.2011.06.004
Title: Identification of a new sildenafil analogue in a health supplement
Authors: Ge, X.
Li, L.
Koh, H.-L. 
Low, M.-Y.
Keywords: Adulterant
Health supplement
MS
NMR
Issue Date: 1-Nov-2011
Source: Ge, X., Li, L., Koh, H.-L., Low, M.-Y. (2011-11-01). Identification of a new sildenafil analogue in a health supplement. Journal of Pharmaceutical and Biomedical Analysis 56 (3) : 491-496. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jpba.2011.06.004
Abstract: A sildenafil analogue was detected and isolated from a health supplement claimed for human use. The structure of this new analogue was elucidated using LC-UV, LC-Orbitrap-MS, IR spectroscopy, 1D and 2D NMR. It was characterized as dithio-desmethylcarbodenafil containing 2 thiocarbonyl groups instead of 2 carbonyl groups, and 4-methyl substitution, on the piperazine ring, rather than 4-ethyl substitution, when compared to sildenafil. © 2011 Elsevier B.V.
Source Title: Journal of Pharmaceutical and Biomedical Analysis
URI: http://scholarbank.nus.edu.sg/handle/10635/106010
ISSN: 07317085
DOI: 10.1016/j.jpba.2011.06.004
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