Please use this identifier to cite or link to this item: https://doi.org/nar/gkq1165
Title: HIT: Linking herbal active ingredients to targets
Authors: Ye, H.
Ye, L.
Kang, H.
Zhang, D.
Tao, L.
Tang, K.
Liu, X.
Zhu, R.
Liu, Q.
Chen, Y.Z. 
Li, Y.
Cao, Z.
Issue Date: Jan-2011
Source: Ye, H., Ye, L., Kang, H., Zhang, D., Tao, L., Tang, K., Liu, X., Zhu, R., Liu, Q., Chen, Y.Z., Li, Y., Cao, Z. (2011-01). HIT: Linking herbal active ingredients to targets. Nucleic Acids Research 39 (SUPPL. 1) : D1055-D1059. ScholarBank@NUS Repository. https://doi.org/nar/gkq1165
Abstract: The information of protein targets and small molecule has been highly valued by biomedical and pharmaceutical research. Several protein target databases are available online for FDA-approved drugs as well as the promising precursors that have largely facilitated the mechanistic study and subsequent research for drug discovery. However, those related resources regarding to herbal active ingredients, although being unusually valued as a precious resource for new drug development, is rarely found. In this article, a comprehensive and fully curated database for Herb Ingredients' Targets (HIT, http://lifecenter.sgst.cn/hit/) has been constructed to complement above resources. Those herbal ingredients with protein target information were carefully curated. The molecular target information involves those proteins being directly/ indirectly activated/inhibited, protein binders and enzymes whose substrates or products are those compounds. Those up/down regulated genes are also included under the treatment of individual ingredients. In addition, the experimental condition, observed bioactivity and various references are provided as well for user's reference. Derived from more than 3250 literatures, it currently contains 5208 entries about 1301 known protein targets (221 of them are described as direct targets) affected by 586 herbal compounds from more than 1300 reputable Chinese herbs, overlapping with 280 therapeutic targets from Therapeutic Targets Database (TTD), and 445 protein targets from DrugBank corresponding to 1488 drug agents. The database can be queried via keyword search or similarity search. Crosslinks have been made to TTD, DrugBank, KEGG, PDB, Uniprot, Pfam, NCBI, TCM-ID and other databases. © The Author(s) 2010.
Source Title: Nucleic Acids Research
URI: http://scholarbank.nus.edu.sg/handle/10635/106001
ISSN: 03051048
DOI: nar/gkq1165
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

WEB OF SCIENCETM
Citations

66
checked on Jan 22, 2018

Page view(s)

30
checked on Feb 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.