Please use this identifier to cite or link to this item: https://doi.org/10.1002/hep.22138
Title: Health-related quality of life in chronic hepatitis B patients
Authors: Siew, C.O.
Mak, B.
Myat, O.A.
Li, S.-C. 
Lim, S.-G.
Issue Date: Apr-2008
Source: Siew, C.O., Mak, B., Myat, O.A., Li, S.-C., Lim, S.-G. (2008-04). Health-related quality of life in chronic hepatitis B patients. Hepatology 47 (4) : 1108-1117. ScholarBank@NUS Repository. https://doi.org/10.1002/hep.22138
Abstract: The relationship between stages of chronic hepatitis B liver disease and health-related quality of life (HRQoL) is an important aspect of the overall management of hepatitis B virus (HBV) infection, yet is not well characterized. Consequently we sought to examine HRQoL in HBV patients, stratified by disease severity, compared with normal controls and hypertensive patients, using the Short Form 36 Health Survey (SF-36) and the EQ-5D self-report questionnaire. Univariate and multivariate analyses were then performed. A total of 432 HBV (156 asymptomatic carriers, 142 chronic hepatitis B, 66 compensated cirrhosis, 24 decompensated cirrhosis, 22 hepatocellular carcinoma, and 22 post-liver transplant) patients, 93 hypertensive patients, and 108 normal controls participated in the study. Multivariate analysis showed that normal controls and asymptomatic carriers had similar SF-36 scores, which were better than those for hypertensive patients, but with development of chronic hepatitis B and compensated cirrhosis, showed a significant decrease in general health and the mental dimension, whereas those with advanced liver disease (decompensated cirrhosis and hepatocellular carcinoma) had significantly lower scores in all components (P < 0.05), indicating that the physical component deteriorates only with advanced liver disease. Similar results were obtained with EQ5D. Post-liver transplant patients had similar HRQoL to patients with decompensated cirrhosis and hepatocellular carcinoma, although there was a trend toward improvement. Conclusion: Our results showed that HRQoL in asymptomatic carriers is comparable to those of normal controls and better than hypertensive patients, but deteriorates with disease progression, initially in general health and mental dimensions, but with advanced disease all dimensions are affected. Copyright © 2008 by the American Association for the Study of Liver Diseases.
Source Title: Hepatology
URI: http://scholarbank.nus.edu.sg/handle/10635/105991
ISSN: 02709139
DOI: 10.1002/hep.22138
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

58
checked on Feb 22, 2018

WEB OF SCIENCETM
Citations

60
checked on Jan 22, 2018

Page view(s)

26
checked on Feb 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.