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|Title:||Factors affecting drug release from drug-coated granules prepared by fluidized-bed coating|
|Authors:||Wan, L.S.C. |
|Source:||Wan, L.S.C.,Lai, W.F. (1991-05-27). Factors affecting drug release from drug-coated granules prepared by fluidized-bed coating. International Journal of Pharmaceutics 72 (2) : 163-174. ScholarBank@NUS Repository.|
|Abstract:||The preparation of drug-coated core formulations where the drug is located on the surface of a lactose granule core, using a methylcellulose (MC) or a hydroxypropylmethylcellulose (HPMC) polymeric system with diphenhydramine hydrochloride as a model drug, was studied. The drug and the polymer were applied onto lactose granules using the fluidized-bed coating method. The intermittent spray conditions adopted were able to minimize aggregation of the granules and the spray drying of the coating liquid. A high coating efficiency of over 97% was obtained and the granules were evenly coated. In vitro drug release from the coated granules was shown to be dependent on the drug loading, hydrophilicity, adhesive properties, viscosity and total amount of the polymer in the drug-polymer coat. The effect of the air entrapped in the coated lactose granules on their release profiles is also discussed. These results have important implications for the design of drug-coated granules as a modified-release dosage form employing a water-soluble polymeric system. © 1991.|
|Source Title:||International Journal of Pharmaceutics|
|Appears in Collections:||Staff Publications|
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