Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/105950
Title: Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo.
Authors: Du, H.Y.
Olivo, M. 
Chen, Y.J.
Yip, G.
Tan, P.H.
Matsumoto, K.
Tsujimoto, M.
Bay, B.H.
Issue Date: Nov-2005
Citation: Du, H.Y.,Olivo, M.,Chen, Y.J.,Yip, G.,Tan, P.H.,Matsumoto, K.,Tsujimoto, M.,Bay, B.H. (2005-11). Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo.. International journal of molecular medicine. 16 (5) : 865-868. ScholarBank@NUS Repository.
Abstract: The Y-Box binding protein, YB-1, belongs to a group in the DNA and RNA binding protein family. YB-1 is known to be expressed in a number of different cancers and reported to protect cells against DNA-damaging agents such as ultraviolet light. The purpose of this study was to determine if YB-1 levels are altered in photodynamic therapy (PDT)-treated nasopharyngeal cancer (NPC) cells. In this report, we show for the first time that YB-1 is expressed at both the mRNA and protein levels in well-differentiated NPC in vivo. YB-1 mRNA expression in tumor tissues from a murine well-differentiated HK1/NPC model showed no significant difference in mRNA levels following hypericin-PDT. Localization of the YB-1 protein by immuno-histochemistry revealed the presence of cytoplasmic YB-1 in the more mature and better differentiated cells of the untreated group, as well as cells that survived PDT treatment. Expression of the YB-1 protein may possibly influence the cellular stress response to hypericin-PDT and protect the cells from phototoxicity.
Source Title: International journal of molecular medicine.
URI: http://scholarbank.nus.edu.sg/handle/10635/105950
ISSN: 11073756
Appears in Collections:Staff Publications

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