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|Title:||Evaluation of permeability and mechanical properties of composite polyvinyl alcohol films|
|Authors:||Chan, L.W. |
|Citation:||Chan, L.W.,Hao, J.S.,Heng, P.W.S. (1999-10). Evaluation of permeability and mechanical properties of composite polyvinyl alcohol films. Chemical and Pharmaceutical Bulletin 47 (10) : 1412-1416. ScholarBank@NUS Repository.|
|Abstract:||Among six grades of polyvinyl alcohol (PVA), PVA V (degree of hydrolysation 99.45%, molecular weight 140000 - 150000) and PVA VI (degree of hydrolysation 98 - 99%, molecular weight 85000 - 146000) were selected for combination with PVA I (degree of hydrolysation 99%, molecular weight 17300) to prepare composite films with different amounts of PVA I and film thickness. The permeability coefficients of diclofenac sodium through these films were determined and the elastic moduli measured. The permeability coefficients increased with the amount of PVA I in the PVA V-I films, conversely, the presence of PVA I in the PVA VI-I films decreased the permeability of the composite films to diclofenac sodium. PVA VI-I films showed significantly higher permeability than PVA V-I films. These results indicated that PVA I content in the composite films was a critical factor, affecting the apparent solubility and/or swelling properties, and thereby permeability of the composite films. For PVA V-I films, the effect of PVA I on increasing solubility played a dominant role, but for PVA VI-I films, the effect of PVA I on decreasing swelling properties was a more important factor. Film thickness also influenced the permeability coefficients of diclofenac sodium through the composite films; film permeability decreasing with increasing film thickness. The addition of PVA I raised the elastic moduli of PVA VI-I film but showed minimal effect on PVA V-I films. Proper selection of PVA grades and weight ratio was the key element to successful preparation of PVA composite films with the desired characteristics.|
|Source Title:||Chemical and Pharmaceutical Bulletin|
|Appears in Collections:||Staff Publications|
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