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|Title:||Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells|
Label-free imaging probe
|Citation:||Gong, T., Olivo, M., Dinish, U.S., Goh, D., Kong, K.V., Yong, K.-T. (2013-06). Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells. Journal of Biomedical Nanotechnology 9 (6) : 985-991. ScholarBank@NUS Repository. https://doi.org/10.1166/jbn.2013.1603|
|Abstract:||In this paper, we proposed the use of gold nanoparticles as plasmon scattering probes for dark-field multiplex imaging of live cancer cells. By carefully engineering the surfaces, aqueous dispersions of anti-EGFR antibody-conjugated gold nanospheres and gold nanorods are prepared. We demonstrated the receptor-mediated delivery of antibody conjugated gold nanospheres and gold nanorods into EGFR receptor-positive oral squamous cell carcinoma cell line by using dark-field microscopy technique. Our result suggests that gold nanospheres and gold nanorods formulations could provide up to 7 types of plasmon scattering probes based on their tunability range with a 100 nm spectral separation in absorption bands. Copyright © 2013 American Scientific Publishers All rights reserved.|
|Source Title:||Journal of Biomedical Nanotechnology|
|Appears in Collections:||Staff Publications|
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