Please use this identifier to cite or link to this item: https://doi.org/10.1166/jbn.2013.1603
Title: Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells
Authors: Gong, T.
Olivo, M. 
Dinish, U.S.
Goh, D.
Kong, K.V.
Yong, K.-T.
Keywords: Cancer cells
Gold nanoparticles
Hyper spectra
Label-free imaging probe
Multiplex imaging
Plasmonics
Issue Date: Jun-2013
Citation: Gong, T., Olivo, M., Dinish, U.S., Goh, D., Kong, K.V., Yong, K.-T. (2013-06). Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells. Journal of Biomedical Nanotechnology 9 (6) : 985-991. ScholarBank@NUS Repository. https://doi.org/10.1166/jbn.2013.1603
Abstract: In this paper, we proposed the use of gold nanoparticles as plasmon scattering probes for dark-field multiplex imaging of live cancer cells. By carefully engineering the surfaces, aqueous dispersions of anti-EGFR antibody-conjugated gold nanospheres and gold nanorods are prepared. We demonstrated the receptor-mediated delivery of antibody conjugated gold nanospheres and gold nanorods into EGFR receptor-positive oral squamous cell carcinoma cell line by using dark-field microscopy technique. Our result suggests that gold nanospheres and gold nanorods formulations could provide up to 7 types of plasmon scattering probes based on their tunability range with a 100 nm spectral separation in absorption bands. Copyright © 2013 American Scientific Publishers All rights reserved.
Source Title: Journal of Biomedical Nanotechnology
URI: http://scholarbank.nus.edu.sg/handle/10635/105922
ISSN: 15507033
DOI: 10.1166/jbn.2013.1603
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