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|Title:||Effects of physical properties of PEG 6000 on pellets produced by melt pelletization|
|Authors:||Wong, T.W. |
|Keywords:||Binder particle size|
|Source:||Wong, T.W., Wan, L.S.C., Heng, P.W.S. (1999). Effects of physical properties of PEG 6000 on pellets produced by melt pelletization. Pharmaceutical Development and Technology 4 (3) : 449-456. ScholarBank@NUS Repository. https://doi.org/10.1081/PDT-100101381|
|Abstract:||This study examined the effects of polyethylene glycol (PEG) binders of different physical forms and from different commercial sources on size and size distribution of pellets produced. The meltable binders used were PEG 6000 in the form of flakes, and coarse and fine powders, and melt pelletization using lactose 450 M was carried out in an 8-liter high-shear mixer. Binder particle size, molecular weight, tack, and viscosity were determined. The results showed that the size and size distribution of the pellets obtained could not be explained by the binder particle size. The size and size distribution of the pellets were related to the tack and viscosity of the molten binders. PEGs used were labeled as the same nominal molecular weight grade, although their determined molecular weights could be quite different. Differences in tack and viscosity of the molten binders were associated with determined molecular weight of the binders. The melt pelletization process is sensitive to tack and viscosity of the molten binders. When different PEG brands of the same nominal molecular weight or different batches of the same brand are used in melt pelletization, it is important to characterize the tack and viscosity of the binders used. The effects of the physical form of binders on the pellet quality appear to be less important when compared to the influences of tack and viscosity of the molten binder.|
|Source Title:||Pharmaceutical Development and Technology|
|Appears in Collections:||Staff Publications|
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