Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/105898
Title: Effects of ingredients on stability of captopril in extemporaneously prepared oral liquids
Authors: Lye, M.Y.F.
Yow, K.L.
Lim, L.Y. 
Chan, S.Y. 
Chan, E. 
Ho, P.C. 
Keywords: Captopril
Chelating agents
Compounding
Edetate disodium
Formulations
Hypotensive agents
Incompatibilities
Liquids
Methylcellulose
Powders
Stability
Storage
Su crose
Tablets
Vehicles
Water
Water for Injection
Issue Date: 1997
Source: Lye, M.Y.F.,Yow, K.L.,Lim, L.Y.,Chan, S.Y.,Chan, E.,Ho, P.C. (1997). Effects of ingredients on stability of captopril in extemporaneously prepared oral liquids. American Journal of Health-System Pharmacy 54 (21) : 2483-2487. ScholarBank@NUS Repository.
Abstract: The stability of captopril in several extemporaneously prepared oral liquid formulations was studied. Captopril 1 mg/mL oral liquid formulations were prepared from either powder or tablets in two grades of water syrup, methylcellulose, and edetate disodium. The liquids were stored at 5 °C in amber glass containers, and samples were removed at intervals up to 30 days for assay of captopril concentration by stability-indicating high-performance liquid chromatography. The pH of the formulations remained fairly stable for 30 days. In general, captopril was more stable in formulations containing captopril from tablets than from powder. Captopril in formulations in which the only vehicle was highly purified water was slightly but not significantly more stable than in formulations made with sterile water for irrigation. Formulations made with undiluted syrup were more stable than formulations in which water was used to dilute syrup or formulations containing methylcellulose. The formulations containing edetate disodium were much more stable than those that lacked this component. The stability of captopril 1 mg/mL in oral liquid formulations was influenced by the captopril source (tablets versus powder) and by the presence of syrup, methylcellulose, and edetate disodium. Captopril in a preparation made with tablets and undiluted syrup was stable for 30 days at 5 °C and the formulation should be palatable.
Source Title: American Journal of Health-System Pharmacy
URI: http://scholarbank.nus.edu.sg/handle/10635/105898
ISSN: 10792082
Appears in Collections:Staff Publications

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