Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2006.09.009
Title: Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats
Authors: Wang, Q.
Tang, X.N.
Wang, L. 
Yenari, M.A.
Ying, W.
Goh, B.-C.
Lee, H.-S.
Wilder-Smith, E.P.
Wong, P.T.
Keywords: DA
Hydroxymethylglutaryl-coenzyme reductase inhibitors
Prefrontal cortex
Rat striatum
Reuptake
Simvastatin
Issue Date: 20-Nov-2006
Citation: Wang, Q., Tang, X.N., Wang, L., Yenari, M.A., Ying, W., Goh, B.-C., Lee, H.-S., Wilder-Smith, E.P., Wong, P.T. (2006-11-20). Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats. Neuroscience Letters 408 (3) : 189-193. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2006.09.009
Abstract: Statins are increasingly being used for the treatment of a variety of conditions beyond their original indication for cholesterol lowering. We previously reported that simvastatin increased dopamine receptors in the rat prefrontal cortex [Q. Wang, W.L. Ting, H. Yang, P.T. Wong, High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase, Br. J. Pharmacol. 144 (2005) 933-939] and restored its downregulation in a model of Parkinson's disease (PD) [Q. Wang, P.H. Wang, C. McLachlan, P.T. Wong, Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats, Brain Res. 1045 (2005) 229-233]. Here we explore the effects of simvastatin treatment on tissue dopamine content and reuptake. Sprague-Dawley rats were given simvastatin (1 and 10 mg kg-1 day-1, p.o.) for 4 weeks. Brain tissue from prefrontal cortex and striatum were taken out for dopamine content and its reuptake. Using high-performance liquid chromatographic-mass spectrometer (HPLC-MS), simvastatin (10 mg kg-1 day-1) was found to increase dopamine content by 110% in the striatum but decreased by 76% in the prefrontal cortex compared with the saline treated group. Dopamine (DA) reuptake was unchanged in both brain regions. These results suggest that chronic treatment with high dose of simvastatin may affect DA tissue level in prefrontal cortex and striatum without changing on DA reuptake. This may have important clinical implications in psychiatric and striatal dopaminergic disorders. © 2006 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/105897
ISSN: 03043940
DOI: 10.1016/j.neulet.2006.09.009
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

17
checked on Jun 15, 2018

WEB OF SCIENCETM
Citations

17
checked on May 21, 2018

Page view(s)

46
checked on Jun 1, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.