Please use this identifier to cite or link to this item:
|Title:||Effect of tabletting compaction pressure on alginate microspheres|
|Authors:||Heng P.W.S |
|Citation:||Heng P.W.S,Chan, L.W.,Liew, C.V.,Ng, T.Y. (2000). Effect of tabletting compaction pressure on alginate microspheres. Journal of Microencapsulation 17 (5) : 553-564. ScholarBank@NUS Repository.|
|Abstract:||Alginate and alginate-hydroxypropylmethylcellulose (HPMC) microspheres were prepared by the emulsification method. The compaction of microspheres for producing tablet dosage forms raises concerns about possible damage to microsphere walls with subsequent unpredictable dissolution rates. The effect of different compaction pressures on the integrity of the microspheres was investigated. The addition of a diluent, microcrystalline cellulose (MCC), was required to make compacts containing alginate and alginate-HPMC microspheres. Compacts containing alginate-HPMC (7:3) microspheres had the highest crushing strength followed by compacts containing alginate-HPMC (9:1) microspheres and alginate microspheres. However, compact crushing strength did not vary significantly with increased compaction pressures over the range of compaction pressures investigated. Differences in the drug release profiles of the original non-compacted and compacted alginate and alginate-HPMC microspheres were slight and not marked. Although dentation and distortion of the microspheres were observed with increasing compaction pressures, the microspheres generally remained intact, with minimal rupture/fracture.|
|Source Title:||Journal of Microencapsulation|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 16, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.