Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejps.2003.09.007
Title: Effect of omeprazole on the anticoagulant activity and the pharmacokinetics of warfarin enantiomers in rats
Authors: Zhou, Q.
Chan, E. 
Keywords: Drug interactions
Omeprazole
Pharmacodynamics
Pharmacokinetics
Rats
Warfarin
Issue Date: Dec-2003
Citation: Zhou, Q., Chan, E. (2003-12). Effect of omeprazole on the anticoagulant activity and the pharmacokinetics of warfarin enantiomers in rats. European Journal of Pharmaceutical Sciences 20 (4-5) : 439-449. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejps.2003.09.007
Abstract: The effect of the proton pump inhibitor omeprazole on the anticoagulation and the pharmacokinetics of warfarin enantiomers was studied in rats. Omeprazole given intraperitoneally in a daily dose of 0.67mg/kg over 8 days had no significant effect on the absorption, distribution and the total serum clearance values of the S- and R-enantiomers of warfarin. Omeprazole did not affect the pre-treatment baseline blood coagulation and the in vitro rat serum protein binding of warfarin enantiomers. In vitro study with rat liver microsomes showed that omeprazole had an inhibitory effect on the hydroxylation of warfarin enantiomers. Results obtained from in vivo urinary excretion study revealed that omeprazole inhibited the formation clearance of both S- and R-form oxidative metabolites, but increased that of the overall reductive metabolites, and the renal clearance of S- and R-enantiomers, of warfarin. As a consequence, the total serum clearance values for warfarin enantiomers remained unchanged and the hypoprothrombinaemic response produced by warfarin was not affected. © 2003 Elsevier B.V. All rights reserved.
Source Title: European Journal of Pharmaceutical Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/105880
ISSN: 09280987
DOI: 10.1016/j.ejps.2003.09.007
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

8
checked on Aug 18, 2018

WEB OF SCIENCETM
Citations

7
checked on Jul 17, 2018

Page view(s)

26
checked on Apr 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.