Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/105875
Title: Effect of methyl vinyl ether/maleic anhydride decadiene cross-polymer on drug release from spheroids coated with water soluble polymers
Authors: Heng, P.W.S. 
Wan, L.S.C. 
Tan, Y.T.F.
Keywords: Drug release
Hydroxypropylmethyl cellulose
Methyl vinyl ether/maleic anhydride decadiene cross-polvmer
Response surface
Sodium carboxymethyl cellulose
Spheroids
Issue Date: Mar-1996
Source: Heng, P.W.S.,Wan, L.S.C.,Tan, Y.T.F. (1996-03). Effect of methyl vinyl ether/maleic anhydride decadiene cross-polymer on drug release from spheroids coated with water soluble polymers. S.T.P. Pharma Sciences 6 (2) : 110-117. ScholarBank@NUS Repository.
Abstract: The ability of an anionic polymer, methyl vinyl ether/maleic anhydride decadiene cross-polymer, to retard the release of cationic chlorpheniramine maleate and non-ionic paracetamol from spheroid coated with hydroxypropylmethyl cellulose or sodium carboxymethyl cellulose was examined. The retardation or inhibition of drug release was due to complexation by ionic binding between the ionic polymer and the oppositely charged drug. However, the release rate of non-ionic drug was not altered by the presence of methyl vinyl ether/maleic anhydride decadiene. In the dissolution medium of water, for hydroxypropylmethyl cellulose-methyl vinyl ether/maleic anhydride decadiene coated spheroids containing chlorpheniramine maleate, an increase in percentage of methyl vinyl ether/maleic anhydride decadiene or an increase in coating level generally prolonged the drug release rate, while for sodium carboxymethyl cellulose-methyl vinyl ether/maleic anhydride decadiene coated spheroids, it was observed that there was a distinct minimum of the release rate constants on the response surface and contour plots. The pH and ionic concentration of the dissolution media also played an important role in controlling drug release. At pH 1, 2 and 7.2, drug polymer complexation was reversible, resulting in a faster drug release rate. Drug release rate in 5 mM phosphate buffer was slower than that in 50 mM phosphate buffer.
Source Title: S.T.P. Pharma Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/105875
ISSN: 11571489
Appears in Collections:Staff Publications

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