Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/105866
DC Field | Value | |
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dc.title | Effect of additives on liquid uptake into hydroxypropylmethylcellulose matrices | |
dc.contributor.author | Wan, L.S.C. | |
dc.contributor.author | Heng, P.W.S. | |
dc.contributor.author | Wong, L.F. | |
dc.date.accessioned | 2014-10-29T01:51:45Z | |
dc.date.available | 2014-10-29T01:51:45Z | |
dc.date.issued | 1994 | |
dc.identifier.citation | Wan, L.S.C.,Heng, P.W.S.,Wong, L.F. (1994). Effect of additives on liquid uptake into hydroxypropylmethylcellulose matrices. S.T.P. Pharma Sciences 4 (3) : 213-219. ScholarBank@NUS Repository. | |
dc.identifier.issn | 11571489 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/105866 | |
dc.description.abstract | The penetration of water into hydroxypropylmethylcellulose (HPMC)/propranolol matrices containing 25% HPMC K15 and varying quantities of an additive was studied. The kinetics of liquid uptake into these matrices was fitted with a second-order polynomial equation incorporating both Fickian Case I diffusion and Case II relaxational models. Lactose improved the Case I uptake into HPMC/propranolol matrices. However, Case I uptake was reduced in matrices with dicalcium phosphate compared with matrices with lactose. Starch had a minimal effect on the overall water uptake profile. It improved Case I transport marginally but did not affect Case II transport. Sodium carboxymethylcellulose (NaCMC) altered the water penetration profile of HPMC/propranolol matrices two-fold. The presence of 50% NaCMC in the matrices encouraged higher water uptake whilst matrices with 25% NaCMC increased the water uptake only during the initial stages. | |
dc.source | Scopus | |
dc.subject | coupled Case I-Case II model | |
dc.subject | dicalcium phosphate | |
dc.subject | hydroxypropylmethylcellulose | |
dc.subject | lactose | |
dc.subject | liquid penetration | |
dc.subject | sodium carboxymethylcellulose | |
dc.subject | starch | |
dc.type | Article | |
dc.contributor.department | PHARMACY | |
dc.description.sourcetitle | S.T.P. Pharma Sciences | |
dc.description.volume | 4 | |
dc.description.issue | 3 | |
dc.description.page | 213-219 | |
dc.description.coden | STSSE | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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