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Title: Effect of additives on liquid uptake into hydroxypropylmethylcellulose matrices
Authors: Wan, L.S.C. 
Heng, P.W.S. 
Wong, L.F.
Keywords: coupled Case I-Case II model
dicalcium phosphate
liquid penetration
sodium carboxymethylcellulose
Issue Date: 1994
Citation: Wan, L.S.C.,Heng, P.W.S.,Wong, L.F. (1994). Effect of additives on liquid uptake into hydroxypropylmethylcellulose matrices. S.T.P. Pharma Sciences 4 (3) : 213-219. ScholarBank@NUS Repository.
Abstract: The penetration of water into hydroxypropylmethylcellulose (HPMC)/propranolol matrices containing 25% HPMC K15 and varying quantities of an additive was studied. The kinetics of liquid uptake into these matrices was fitted with a second-order polynomial equation incorporating both Fickian Case I diffusion and Case II relaxational models. Lactose improved the Case I uptake into HPMC/propranolol matrices. However, Case I uptake was reduced in matrices with dicalcium phosphate compared with matrices with lactose. Starch had a minimal effect on the overall water uptake profile. It improved Case I transport marginally but did not affect Case II transport. Sodium carboxymethylcellulose (NaCMC) altered the water penetration profile of HPMC/propranolol matrices two-fold. The presence of 50% NaCMC in the matrices encouraged higher water uptake whilst matrices with 25% NaCMC increased the water uptake only during the initial stages.
Source Title: S.T.P. Pharma Sciences
ISSN: 11571489
Appears in Collections:Staff Publications

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