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|Title:||Effect of additives on liquid uptake into hydroxypropylmethylcellulose matrices|
|Authors:||Wan, L.S.C. |
|Keywords:||coupled Case I-Case II model|
|Source:||Wan, L.S.C.,Heng, P.W.S.,Wong, L.F. (1994). Effect of additives on liquid uptake into hydroxypropylmethylcellulose matrices. S.T.P. Pharma Sciences 4 (3) : 213-219. ScholarBank@NUS Repository.|
|Abstract:||The penetration of water into hydroxypropylmethylcellulose (HPMC)/propranolol matrices containing 25% HPMC K15 and varying quantities of an additive was studied. The kinetics of liquid uptake into these matrices was fitted with a second-order polynomial equation incorporating both Fickian Case I diffusion and Case II relaxational models. Lactose improved the Case I uptake into HPMC/propranolol matrices. However, Case I uptake was reduced in matrices with dicalcium phosphate compared with matrices with lactose. Starch had a minimal effect on the overall water uptake profile. It improved Case I transport marginally but did not affect Case II transport. Sodium carboxymethylcellulose (NaCMC) altered the water penetration profile of HPMC/propranolol matrices two-fold. The presence of 50% NaCMC in the matrices encouraged higher water uptake whilst matrices with 25% NaCMC increased the water uptake only during the initial stages.|
|Source Title:||S.T.P. Pharma Sciences|
|Appears in Collections:||Staff Publications|
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