Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0039782
Title: Drug discovery prospect from untapped species: Indications from approved natural product drugs
Authors: Zhu, F. 
Ma, X.H. 
Qin, C.
Tao, L.
Liu, X.
Shi, Z.
Zhang, C.L.
Tan, C.Y.
Chen, Y.Z. 
Jiang, Y.Y.
Issue Date: 11-Jul-2012
Citation: Zhu, F., Ma, X.H., Qin, C., Tao, L., Liu, X., Shi, Z., Zhang, C.L., Tan, C.Y., Chen, Y.Z., Jiang, Y.Y. (2012-07-11). Drug discovery prospect from untapped species: Indications from approved natural product drugs. PLoS ONE 7 (7) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0039782
Abstract: Due to extensive bioprospecting efforts of the past and technology factors, there have been questions about drug discovery prospect from untapped species. We analyzed recent trends of approved drugs derived from previously untapped species, which show no sign of untapped drug-productive species being near extinction and suggest high probability of deriving new drugs from new species in existing drug-productive species families and clusters. Case histories of recently approved drugs reveal useful strategies for deriving new drugs from the scaffolds and pharmacophores of the natural product leads of these untapped species. New technologies such as cryptic gene-cluster exploration may generate novel natural products with highly anticipated potential impact on drug discovery. © 2012 Zhu et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/105852
ISSN: 19326203
DOI: 10.1371/journal.pone.0039782
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