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Title: Development and optimization of solid dispersion containing pellets of itraconazole prepared by high shear pelletization
Authors: Ye, G.
Wang, S.
Heng, P.W.S. 
Chen, L.
Wang, C.
Keywords: Central composite design
Dissolution enhancement
High shear pelletization
Pellet characteristics
Solid dispersion
Issue Date: 7-Jun-2007
Citation: Ye, G., Wang, S., Heng, P.W.S., Chen, L., Wang, C. (2007-06-07). Development and optimization of solid dispersion containing pellets of itraconazole prepared by high shear pelletization. International Journal of Pharmaceutics 337 (1-2) : 80-87. ScholarBank@NUS Repository.
Abstract: This study investigated the solid dispersion containing pellets of itraconazole for enhanced drug dissolution rate. The influence of process parameters used during high shear pelletization on the pellet properties including pellet size and dissolution rate was also studied. Solid dispersions of itraconazole were prepared with Eudragit® E100, a hydrophilic polymer, by a simple fusion method followed by powdered and characterized by differential scanning calorimetry and X-ray powder diffraction. Solid dispersions containing pellets were consequently prepared using a lab-scale high shear mixer. In order to improve the product quality, a central composite design was applied to optimize the critical process variables, such as impeller speed and kneading time, and the results were modeled statistically. Itraconazole was presented as an amorphous state in the solid dispersion prepared at a drug to polymer ratio of 1:2. Both studied parameters had great effect on the responses. Powdered solid dispersion and pellets prepared using the optimal parameter settings showed approximately 30- and 70-fold increases in dissolution rate over the pure drug, respectively. Solid dispersion prepared by simple fusion method could be an option for itraconazole solubility enhancement. Pelletization process in high shear mixer can be optimized effectively by central composite design. © 2006 Elsevier B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2006.12.028
Appears in Collections:Staff Publications

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