Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0378-5173(02)00169-2
Title: Cross-linking mechanisms of calcium and zinc in production of alginate microspheres
Authors: Chan, L.W. 
Jin, Y.
Heng, P.W.S. 
Keywords: Alginate
Calcium
Microspheres
Viscosity
Zinc
Issue Date: 21-Aug-2002
Citation: Chan, L.W., Jin, Y., Heng, P.W.S. (2002-08-21). Cross-linking mechanisms of calcium and zinc in production of alginate microspheres. International Journal of Pharmaceutics 242 (1-2) : 255-258. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-5173(02)00169-2
Abstract: Calcium chloride and zinc sulphate were used to cross-link alginate microspheres prepared by an emulsification method. The microspheres cross-linked by a combination of these two salts showed different morphology and slower drug release compared with those cross-linked by the calcium salt alone. From viscosity study, it was found that zinc cations interacted with the alginate molecules to a greater extent than calcium cations. The varying effects of the salts on the properties of the microspheres were largely attributed to their ability to interact with the alginate molecules. © 2002 Elsevier Science B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/105786
ISSN: 03785173
DOI: 10.1016/S0378-5173(02)00169-2
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