Please use this identifier to cite or link to this item:
|Title:||Comparison of surface roughness parameters obtained by scanning probe microscopy for carrier particles of dry powder inhalers|
|Authors:||Chan, L.W. |
|Keywords:||Dry powder inhalers|
Lactose carrier particles
Scanning probe microscopy
Surface roughness parameters
|Source:||Chan, L.W.,Zhou, Q.,Heng, P.W.S. (2007-05). Comparison of surface roughness parameters obtained by scanning probe microscopy for carrier particles of dry powder inhalers. Journal of Drug Delivery Science and Technology 17 (3) : 217-222. ScholarBank@NUS Repository.|
|Abstract:||Surface 3-D profiles of carrier particles for dry powder inhalers (DPIs) were obtained by scanning probe microscopy (SPM) and analyzed using various roughness parameters. Different roughness parameters were compared and evaluated for their suitability for distinctively quantifying the surface roughness of the lactose carrier particles. Arithmetic mean roughness (Ra) was found to be the most sensitive for differentiating the surface roughness of various lactose carriers while fractal dimension (FD) and surface ratio (SR) were less sensitive. On the other hand, maximum height (Ry) and 10-point mean roughness (Rz) were less representative of the roughness of the whole surface due to the methods of calculation involved. Scan area was found to be an important factor affecting the roughness results obtained and should be seriously considered in the measurement of surface roughness.|
|Source Title:||Journal of Drug Delivery Science and Technology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 10, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.