Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11095-009-9865-7
Title: Comparing the relative oxidative DNA damage caused by various arsenic species by quantifying urinary levels of 8-hydroxy-2′-deoxyguanosine with isotope-dilution liquid chromatography/mass spectrometry
Authors: Wu, J.-Z.
Ho, P.C. 
Keywords: 8-hydroxy-2′- deoxyguanosine
Arsenite
Orpiment
Oxidative DNA damage
Realgar
Issue Date: Jun-2009
Citation: Wu, J.-Z., Ho, P.C. (2009-06). Comparing the relative oxidative DNA damage caused by various arsenic species by quantifying urinary levels of 8-hydroxy-2′-deoxyguanosine with isotope-dilution liquid chromatography/mass spectrometry. Pharmaceutical Research 26 (6) : 1525-1533. ScholarBank@NUS Repository. https://doi.org/10.1007/s11095-009-9865-7
Abstract: Purpose: To investigate the association between various arsenicals and the potential oxidative stress caused, we examined the urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OH-dGuo), a biomarker of oxidative DNA damage in rats after daily oral administration of arsenic trioxide/arsenite (As2O3), realgar (α-As4S4) and orpiment (As2S3) over 14 days and compared the levels with control rats. Methods: 8-OH-dGuo in urine was quantified with isotope-dilution liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) after sample cleaning with solid phase extraction (SPE). Urinary arsenic concentrations were measured by graphite furnace atomic absorption spectrometry (GFAAS). Results: All arsenicals caused elevated urinary 8-OH-dGuo excretion in rats from day 1 after oral administration (p∈
Source Title: Pharmaceutical Research
URI: http://scholarbank.nus.edu.sg/handle/10635/105754
ISSN: 07248741
DOI: 10.1007/s11095-009-9865-7
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Oct 15, 2018

WEB OF SCIENCETM
Citations

9
checked on Nov 22, 2017

Page view(s)

30
checked on Sep 14, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.