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|Title:||Comparing the relative oxidative DNA damage caused by various arsenic species by quantifying urinary levels of 8-hydroxy-2′-deoxyguanosine with isotope-dilution liquid chromatography/mass spectrometry|
Oxidative DNA damage
|Citation:||Wu, J.-Z., Ho, P.C. (2009-06). Comparing the relative oxidative DNA damage caused by various arsenic species by quantifying urinary levels of 8-hydroxy-2′-deoxyguanosine with isotope-dilution liquid chromatography/mass spectrometry. Pharmaceutical Research 26 (6) : 1525-1533. ScholarBank@NUS Repository. https://doi.org/10.1007/s11095-009-9865-7|
|Abstract:||Purpose: To investigate the association between various arsenicals and the potential oxidative stress caused, we examined the urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OH-dGuo), a biomarker of oxidative DNA damage in rats after daily oral administration of arsenic trioxide/arsenite (As2O3), realgar (α-As4S4) and orpiment (As2S3) over 14 days and compared the levels with control rats. Methods: 8-OH-dGuo in urine was quantified with isotope-dilution liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) after sample cleaning with solid phase extraction (SPE). Urinary arsenic concentrations were measured by graphite furnace atomic absorption spectrometry (GFAAS). Results: All arsenicals caused elevated urinary 8-OH-dGuo excretion in rats from day 1 after oral administration (p∈|
|Source Title:||Pharmaceutical Research|
|Appears in Collections:||Staff Publications|
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