Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0968-0896(99)00051-6
Title: Combinatorial mixture synthesis and biological evaluation of dihydrophenyl triazine antifolates
Authors: Lee, H.-K.
Chui, W.-K. 
Keywords: Antifolates
Combinatorial synthesis
Dihydrofolate reductase
Enzyme inhibitors
Issue Date: Jun-1999
Citation: Lee, H.-K., Chui, W.-K. (1999-06). Combinatorial mixture synthesis and biological evaluation of dihydrophenyl triazine antifolates. Bioorganic and Medicinal Chemistry 7 (6) : 1255-1262. ScholarBank@NUS Repository. https://doi.org/10.1016/S0968-0896(99)00051-6
Abstract: The traditional 'one-pot' three component synthesis was adapted successfully for combinatorial mixtures synthesis of dihydrophenyl triazines, which are nonclassical, dihydrofolate reductase (DHFR) inhibitors. Each library was designed to comprise eight reaction mixture pots and in every pot there were three dihydrophenyl triazines. A total of three libraries were synthesized and the final number of compounds harvested was 64. The products precipitated out of the reaction mixture and could be collected easily and cleansed by washing. Solid supports and further purification processes were not required. The reactions were monitored by TLC and a HPLC method was developed to determine the number of products in each pot. All 24 pots were screened for inhibitory activity against the rat liver DHFR. Two pots showed good inhibitory activity and the products in them were individually synthesized, characterized and biologically tested again. One lead compound was identified amongst all the compounds synthesized, and would be further optimized. Copyright (C) 1999 Elsevier Science Ltd.
Source Title: Bioorganic and Medicinal Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/105745
ISSN: 09680896
DOI: 10.1016/S0968-0896(99)00051-6
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