Please use this identifier to cite or link to this item:
|Title:||Colon-specific delivery of resveratrol: Optimization of multi-particulate calcium-pectinate carrier|
|Source:||Das, S., Ng, K.-Y. (2010-01-29). Colon-specific delivery of resveratrol: Optimization of multi-particulate calcium-pectinate carrier. International Journal of Pharmaceutics 385 (1-2) : 20-28. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpharm.2009.10.016|
|Abstract:||This study aimed at devising multi-particulate calcium-pectinate (Ca-pectinate) bead formulations for colon-targeted delivery of resveratrol. As Ca-pectinate beads were not sufficient to endure the upper GI environment and premature release of resveratrol occurred before their arrival to the colon, the beads were hardened by adding polyethyleneimine (PEI) in the cross-linking solution. The effects of PEI concentration, cross-linking time, and pectin to resveratrol ratio were investigated on beads' characteristics, encapsulation efficiency, swelling-erosion, and resveratrol retention pattern of formulated beads. Proper conditions were optimized from these studies and optimized beads were further subjected to morphological examination. Formulated beads were spherical with ∼1 mm diameter. Addition of PEI to the cross-linking solution and a minimum cross-linking time were found to be crucial factors for colon-specific release of resveratrol. As PEI was added in the cross-linking solution, hardening of the bead surface occurred simultaneously with bead formation. Observations from the present study revealed that optimized Ca-pectinate beads hardened with PEI can efficiently encapsulate resveratrol and have potential for colon-specific delivery to the lower GI tract. © 2009 Elsevier B.V. All rights reserved.|
|Source Title:||International Journal of Pharmaceutics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 22, 2018
WEB OF SCIENCETM
checked on Jan 29, 2018
checked on Feb 19, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.