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|Title:||Antimalarial activity of ferrocenyl chalcones|
|Citation:||Wu, X., Wilairat, P., Go, M.-L. (2002-09-02). Antimalarial activity of ferrocenyl chalcones. Bioorganic and Medicinal Chemistry Letters 12 (17) : 2299-2302. ScholarBank@NUS Repository. https://doi.org/10.1016/S0960-894X(02)00430-4|
|Abstract:||A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC50 of 4.5 and 5.1 μM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. © 2002 Elsevier Science Ltd. All rights reserved.|
|Source Title:||Bioorganic and Medicinal Chemistry Letters|
|Appears in Collections:||Staff Publications|
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