Please use this identifier to cite or link to this item: https://doi.org/10.1002/lpor.201200059
Title: Advances in fluorescence diagnosis to track footprints of cancer progression in vivo
Authors: Olivo, M. 
Ho, C.J.H.
Fu, C.Y.
Keywords: Biomarkers
Cancer
Diagnostics
Fluorescence correlation spectroscopy
Fluorescence lifetime
Fluorescence spectroscopy and imaging
In vivo
Molecular imaging
Nanoparticle probes
Photodynamic diagnosis
Tomography
Issue Date: Sep-2013
Citation: Olivo, M., Ho, C.J.H., Fu, C.Y. (2013-09). Advances in fluorescence diagnosis to track footprints of cancer progression in vivo. Laser and Photonics Reviews 7 (5) : 646-662. ScholarBank@NUS Repository. https://doi.org/10.1002/lpor.201200059
Abstract: Fluorescence spectroscopy and imaging have been widely used for in vivo cancer diagnosis and therapy monitoring in preclinical models, as well as clinical translation. Great attempts have been made to develop novel fluorescence techniques and improve on existing ones, which can now be used in conjunction with newly developed fluorescent probes for specific cancer imaging. In this review, a broad overview of fluorescence techniques is provided, including photodynamic diagnosis, laser confocal endomicroscopy and fluorescence lifetime imaging, coupled with endogenous and exogenous fluorophores. In particular, endogenous fluorophores, such as nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), are highlighted as they are linked to cellular metabolism in precancer growth. The use of near-infrared dyes, such as indocynanine green (ICG), for imaging deep-tissue regions is also reviewed. In addition, diagnostic algorithms used for tissue classification and cancer detection will be discussed. Lastly, emerging technologies in fluorescence diagnosis will also be included. © 2013 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Laser and Photonics Reviews
URI: http://scholarbank.nus.edu.sg/handle/10635/105623
ISSN: 18638880
DOI: 10.1002/lpor.201200059
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