Please use this identifier to cite or link to this item: https://doi.org/10.1002/pds.3293
Title: A retrospective study on the usage of antiepileptic drugs in Asian children from 2000 to 2009 in the largest pediatric hospital in Singapore
Authors: Tan, W.W.
Kong, S.T.
Chan, D.W.
Ho, P.C. 
Keywords: Antiepileptic drugs
Drug utilization
Pediatrics
Pharmacoepidemiology
Seizure control
Therapeutic drug monitoring
Valproic acid
Issue Date: Oct-2012
Citation: Tan, W.W., Kong, S.T., Chan, D.W., Ho, P.C. (2012-10). A retrospective study on the usage of antiepileptic drugs in Asian children from 2000 to 2009 in the largest pediatric hospital in Singapore. Pharmacoepidemiology and Drug Safety 21 (10) : 1074-1080. ScholarBank@NUS Repository. https://doi.org/10.1002/pds.3293
Abstract: Purpose: In light of the increasing usage of the newer antiepileptic drugs (AEDs) in other countries, we reviewed the prescribing pattern of AEDs in Singapore over the last 10years (2000-2009). Methods: A retrospective review of pharmacy dispensing records solicited from the only children's hospital in Singapore was performed to analyze the trend in AEDs prescribing in the last 10years. We also examined the correlation between the serum concentrations of valproic acid (VPA), the most-prescribed AED, and seizure control. Descriptive and inferential statistical analyses were then performed on the findings. Results: A total of 41671 prescriptions on AEDs were retrieved and analyzed. Despite the introduction of the second-generation AEDs, the first generation AEDs still dominate epilepsy treatment in Asian children, with VPA being the mostly prescribed AED (about 40% of the total AEDs usage). The majority of patients (62.8%) were on monotherapy. The mean VPA serum concentration in patients with good seizure control was 68.6μg/ml (SD=26.4μg/ml; range=12.2-138.0 μg/ml), which was statistically higher than the mean VPA concentration of 57.7 μg/ml (SD=27.1μg/ml; range=11.1-149.0 μg/ml) in patients with poor seizure control (p
Source Title: Pharmacoepidemiology and Drug Safety
URI: http://scholarbank.nus.edu.sg/handle/10635/105591
ISSN: 10538569
DOI: 10.1002/pds.3293
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