Please use this identifier to cite or link to this item:
Title: A novel dextran-oleate-cRGDfK conjugate for self-assembly of nanodrug
Authors: Wang, Z.
Lee, T.Y.
Ho, P.C. 
Keywords: Cyclic (Arg-Gly-Asp-D-Phe-Lys) (cRGDfk)
Poly(ethylene glycol)
Issue Date: Feb-2012
Citation: Wang, Z., Lee, T.Y., Ho, P.C. (2012-02). A novel dextran-oleate-cRGDfK conjugate for self-assembly of nanodrug. Nanomedicine: Nanotechnology, Biology, and Medicine 8 (2) : 194-203. ScholarBank@NUS Repository.
Abstract: We report a novel synthetic biocompatible material: a conjugate with a fatty acid-substituted dextran decorated with cRGDfK peptide, which was used as a stable coating material instead of the conventional poly(ethylene glycol) for nanodrug preparation. This novel dextran-oleate-cRGDfK conjugate (DO-cRGDfk) could self-assemble into a micellar structure in aqueous solution, and was used as a surfactant to formulate nanodrug with poly(d,l-lactic-co-glycolic) acid as matrix to encapsulate paclitaxel with high drug-loading efficiency. The conjugate allowed the fabrication of nanodrug with a targeting moiety on its surface in a simple and robust step. The resultant nanoparticles could induce cellular apoptosis more effectively than that of the commercial paclitaxel formulation, Taxol. Thus, DO-cRGDfk could be used as an alternative to poly(ethylene glycol) as a biocompatible surface coating polymeric material for nanoparticle preparation. From the Clinical Editor: The authors describe a novel synthetic biocompatible conjugate, which consists of a fatty acid-substituted dextran decorated with cRGDfK peptide. This conjugate was used as a stable coating material for nanodrug preparation, and can be used in place of conventional PEG. © 2012 Elsevier Inc.
Source Title: Nanomedicine: Nanotechnology, Biology, and Medicine
ISSN: 15499634
DOI: 10.1016/j.nano.2011.06.006
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 16, 2019


checked on Jan 7, 2019

Page view(s)

checked on Dec 14, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.