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|Title:||Linkage disequilibrium mapping of quantitative-trait loci by selective genotyping|
|Authors:||Chen, Z. |
|Source:||Chen, Z., Zheng, G., Ghosh, K., Li, Z. (2005-10). Linkage disequilibrium mapping of quantitative-trait loci by selective genotyping. American Journal of Human Genetics 77 (4) : 661-669. ScholarBank@NUS Repository. https://doi.org/10.1086/491658|
|Abstract:||The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin's original TS approach. © 2005 by The American Society of Human Genetics. All rights reserved.|
|Source Title:||American Journal of Human Genetics|
|Appears in Collections:||Staff Publications|
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