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Title: Trends in exploration of therapeutic targets
Authors: Zheng, C.J. 
Han, L.Y. 
Yap, C.W. 
Xie, B.
Chen, Y.Z. 
Issue Date: Mar-2005
Citation: Zheng, C.J., Han, L.Y., Yap, C.W., Xie, B., Chen, Y.Z. (2005-03). Trends in exploration of therapeutic targets. Drug News and Perspectives 18 (2) : 109-127. ScholarBank@NUS Repository.
Abstract: Lead discovery against a preselected therapeutic target is a key component in modern drug development. Continuous effort and increasing interest has been directed at the search for new targets, which has led to the identification of a growing number of them. Data from the therapeutic target database, at cjttd/ttd.asp, show that, as of July 2004, the number of documented targets of marketed and investigational drugs has reached 1,174 distinct proteins (including subtypes) and 27 nucleic acids, 239 of which are targets of the marketed drugs. Analysis of these targets, particularly those of recently approved drugs and patented investigational agents, provide useful hints about general trends of target exploration and current focus in drug discovery for the treatment of high impact diseases needing effective or more treatment options. © 2005 Prous Science. All rights reserved.
Source Title: Drug News and Perspectives
ISSN: 02140934
DOI: 10.1358/dnp.2005.18.2.886480
Appears in Collections:Staff Publications

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