Please use this identifier to cite or link to this item: https://doi.org/10.1109/ICCABS.2011.5729883
Title: Network model and efficient method for detecting relative duplications or horizontal gene transfers
Authors: Zhang, L. 
Ng, Y.K.
Wu, T. 
Zheng, Y.
Keywords: Gene duplication
Gene loss
Gene tree and species tree reconciliation
Horizontal gene transfer
Phylogenetic network
Issue Date: 2011
Citation: Zhang, L.,Ng, Y.K.,Wu, T.,Zheng, Y. (2011). Network model and efficient method for detecting relative duplications or horizontal gene transfers. 2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2011 : 214-219. ScholarBank@NUS Repository. https://doi.org/10.1109/ICCABS.2011.5729883
Abstract: Background: Horizontal gene transfer and gene duplication are two significant forces behind genome evolution. As more and more well-supported examples of HGTs are being revealed, there is a growing awareness that HGT is more widespread than previously thought, occurring often not only within bacteria, but also between species remotely related such as bacteria and plants or plants and animals. Although a substantial number of genomic sequences are known, HGT inference remains challenging. Parsimony-based inferences of HGT events are typically NP-hard under the framework of gene tree and species tree comparison; it is even more timeconsuming if the maximum likelihood approach is used. The fact that gene tree and species tree incongruence can be further confounded by gene duplication and gene loss events motivates us to incorporate considerations for these events into our inference of HGT events. Similarly, it will be beneficial if known HGT events are considered in the inference of gene duplications and gene losses. © 2011 IEEE.
Source Title: 2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2011
URI: http://scholarbank.nus.edu.sg/handle/10635/104593
ISBN: 9781612848525
DOI: 10.1109/ICCABS.2011.5729883
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