Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/102580
Title: Trends in the exploration of anticancer targets and strategies in enhancing the efficacy of drug targeting.
Authors: Zhu, F. 
Zheng, C.J. 
Han, L.Y. 
Xie, B.
Jia, J.
Liu, X.
Tammi, M.T. 
Yang, S.Y.
Wei, Y.Q.
Chen, Y.Z. 
Issue Date: Nov-2008
Source: Zhu, F.,Zheng, C.J.,Han, L.Y.,Xie, B.,Jia, J.,Liu, X.,Tammi, M.T.,Yang, S.Y.,Wei, Y.Q.,Chen, Y.Z. (2008-11). Trends in the exploration of anticancer targets and strategies in enhancing the efficacy of drug targeting.. Current molecular pharmacology 1 (3) : 213-232. ScholarBank@NUS Repository.
Abstract: A number of therapeutic targets have been explored for developing anticancer drugs. Continuous efforts have been directed at the discovery of new targets as well as the improvement of therapeutic efficacy of agents directed at explored targets. There are 84 and 488 targets of marketed and investigational drugs for the treatment of cancer or cancer related illness. Analysis of these targets, particularly those of drugs in clinical trials and US patents, provides useful information and perspectives about the trends, strategies and progresses in targeting key cancer-related processes and in overcoming the difficulties in developing efficacious drugs against these targets. The efficacy of anticancer drugs directed at these targets is frequently compromised by counteractive molecular interactions and network crosstalk, negative and adverse secondary effects of drugs, and undesired ADMET profiles. Multi-component therapies directed at multiple targets and improved drug targeting methods are being explored for alleviating these efficacy-reducing processes. Investigation of the modes of actions of these combinations and targeting methods offers clues to aid the development of more effective anticancer therapies.
Source Title: Current molecular pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/102580
ISSN: 18744702
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

32
checked on Jan 19, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.