Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mrfmmm.2008.08.009
Title: Transcriptional and epigenetic regulations of embryonic stem cells
Authors: Ng, J.-H.
Heng, J.-C.D.
Loh, Y.-H.
Ng, H.-H. 
Keywords: Embryonic stem cell
Epigenetics
Pluripotency
Self-renewal
Transcriptional regulatory network
Issue Date: 1-Dec-2008
Citation: Ng, J.-H., Heng, J.-C.D., Loh, Y.-H., Ng, H.-H. (2008-12-01). Transcriptional and epigenetic regulations of embryonic stem cells. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 647 (1-2) : 52-58. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mrfmmm.2008.08.009
Abstract: Embryonic stem cells (ESCs) are characterized by their broad developmental potential and the capacity to self-renew. The advent of high-throughput technologies has facilitated genome-wide studies of transcriptional network, resulting in an ever-increasing repertoire of transcription factors implicated in the maintenance of the embryonic stem cell state. While the transcriptional circuitry continues to expand, epigenetic regulation has also gained attention as an important process in stem cell function. Herein, we discuss the recent advancements made in understanding the transcriptional and epigenetic regulations of embryonic stem cells. © 2008.
Source Title: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
URI: http://scholarbank.nus.edu.sg/handle/10635/102575
ISSN: 00275107
DOI: 10.1016/j.mrfmmm.2008.08.009
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