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Title: The intriguing world of prothrombin activators from snake venom
Authors: Kini, R.M. 
Keywords: Anticoagulant
Blood clotting
Factor Xa
Procoagulant proteins
Prothrombin activator
Prothrombinase complex
Serine proteinase
Issue Date: 15-Jun-2005
Citation: Kini, R.M. (2005-06-15). The intriguing world of prothrombin activators from snake venom. Toxicon 45 (8) : 1133-1145. ScholarBank@NUS Repository.
Abstract: Activation of prothrombin to mature thrombin occurs by the proteolytic action of the prothrombinase complex consisting of a serine proteinase factor Xa, and cofactors factor Va, Ca2+ ions and phospholipids. Several exogenous prothrombin activators are found in snake venom. They are classified into four groups based on their cofactor requirements. Group A and B prothrombin activators are metalloproteinases whereas group C and D prothrombin activators are serine proteinases. Group C prothrombin activators resemble the mammalian factor Xa-factor Va complex, while Group D activators are structurally and functionally similar to factor Xa. This review provides a detailed description of the current knowledge on all prothrombin activators and highlights several intriguing questions that are yet to be answered. © 2005 Elsevier Ltd. All rights reserved.
Source Title: Toxicon
ISSN: 00410101
DOI: 10.1016/j.toxicon.2005.02.019
Appears in Collections:Staff Publications

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