Please use this identifier to cite or link to this item:
|Title:||Non-conventional toxins from Elapid venoms|
Muscle nicotinic acetylcholine receptor
Neuronal α7 nicotinic acetylcholine receptor
|Source:||Nirthanan, S., Gopalakrishnakone, P., Gwee, M.C.E., Khoo, H.E., Kini, R.M. (2003-04-01). Non-conventional toxins from Elapid venoms. Toxicon 41 (4) : 397-407. ScholarBank@NUS Repository. https://doi.org/10.1016/S0041-0101(02)00388-4|
|Abstract:||Non-conventional toxins constitute a poorly characterized class of three-finger toxins isolated exclusively from Elapidae venoms. These toxins are monomers of 62-68 amino acid residues and contain five disulfide bridges. However, unlike α/κ-neurotoxins and κ-neurotoxins which have the fifth disulfide bridge in their middle loop (loop II), the fifth disulfide bridge in non-conventional toxins is located in loop I (N-terminus loop). Overall, non-conventional toxins share ∼28-42% identity with other three-finger toxins including α-neurotoxins, α/κ-neurotoxins and κ-neurotoxins. Recent structural studies have revealed that non-conventional toxins also display the typical three-finger motif. Non-conventional toxins are typically characterized by a lower order of toxicity (LD50∼5-80mg/kg) in contrast to prototype α-neurotoxins (LD50∼0.04-0.3mg/kg) and hence they are also referred to as 'weak toxins'. Further, it is generally assumed that non-conventional toxins target muscle (α2βγδ) receptors with low affinities several orders of magnitude lower than α-neurotoxins and α/κ-neurotoxins. However, it is now known that some non-conventional toxins also antagonize neuronal α7 nicotinic acetylcholine receptors. Hence, non-conventional toxins are not a functionally homogeneous group and other, yet unknown, molecular targets for this class of snake venom toxins may exist. Non-conventional toxins may therefore be a useful source of ligands with novel biological activity targeting the plethora of neuronal nicotinic receptors as well as other physiological processes. © 2003 Elsevier Science Ltd. All rights reserved.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 16, 2018
WEB OF SCIENCETM
checked on Nov 17, 2017
checked on Jan 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.