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|Title:||Systems Biology and Stem Cell Biology|
|Authors:||Ng, H.-H. |
|Source:||Ng, H.-H.,Zhong, S.,Lim, B. (2010). Systems Biology and Stem Cell Biology. Systems Biomedicine : 153-173. ScholarBank@NUS Repository. https://doi.org/10.1016/B978-0-12-372550-9.00007-9|
|Abstract:||This chapter examines the importance of systems biology and stem cells and discusses their potential in regenerative medicines. Stem cells are unspecialized and undifferentiated cells that retain the ability to differentiate into specialized cell types. Among the different stem cells, embryonic stem (ES) cells are considered the most pluripotent as they have the potential to form every cell type, including other somatic stem cells. ES cells also possess the capability for extensive self-renewing division in culture. Systems biology requires comprehensive and quantitative measurements of the molecular events in the cells. A major challenge in the study of ES cells is to explain how the complex gene network is "wired" to control their properties of pluripotency and self renewal. A measure of the usefulness of a systems biology approach to the integration and useof stem cell genomic information is whether it is possible to make accurate predictions of cellular responses upon manipulation of genes or extracellular signals. The new knowledge garnered will provide new strategies for engineering cell fate. The concerted effort in studying ES cells makes them a good cellular model for systems biology. Another area where systems biology has also made its impact and will likely continue to do so is in the area of reprogramming. With the derivation and rapid advances in the use of ES cells, fusion of ES with other cell types demonstrated the dominant phenotype of ES cells and strongly suggests the presence of factors that are capable of initiating reprogramming. A systems approach may also continue to shed light on the mechanism for how reprogramming is initiated to establish the epigenome of a pluripotent cell. © 2010 Elsevier Inc. All rights reserved.|
|Source Title:||Systems Biomedicine|
|Appears in Collections:||Staff Publications|
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