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Title: Application of plant viruses as nano drug delivery systems
Authors: Ren, Y.
Wong, S.M. 
Lim, L.Y.
Keywords: coat protein
drug delivery
plant virus
protein cage
Issue Date: Nov-2010
Source: Ren, Y., Wong, S.M., Lim, L.Y. (2010-11). Application of plant viruses as nano drug delivery systems. Pharmaceutical Research 27 (11) : 2509-2513. ScholarBank@NUS Repository.
Abstract: Nano-sized drug delivery systems based on virus-derived platforms have promising delivery and targeting efficiencies. To date, much of our understanding of these systems is obtained from studies of animal viruses. Application of plant viruses for drug delivery is in the nascent stage, but it is becoming apparent that plant viral particles can be engineered to possess novel properties to meet the unique requirements of targeted drug delivery. Chemical functionalization of a plant viral particle surface can impart stealth properties to prolong in vivo circulation half-life and/or targeting capability to direct drug delivery to diseased tissues. The amino acid sequence of the viral coat protein can be genetically manipulated to yield protein cages of specific chemistry and morphology, while the conformation of the protein cage can be directed, via the external environment, to disassemble, then reassemble in vitro to exchange native viral genomic material with exogenous cargo. The purpose of this commentary is to evaluate current literature to assess the potential of nano-scale plant-virus-based drug delivery systems for the targeted delivery of chemotherapeutic agents. © 2010 Springer Science+Business Media, LLC.
Source Title: Pharmaceutical Research
ISSN: 07248741
DOI: 10.1007/s11095-010-0251-2
Appears in Collections:Staff Publications

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