Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/102231
Title: Rapid microwell prototyping, generation of 3D multicellular cancer aggregates, and emt drug screening
Authors: Tu, T.-Y.
Sun, W.
Peng, W.K.
Wang, Z.
Huang, R.Y.J.
Matsudaira, P.T. 
Thiery, J.-P.
Kamm, R.D.
Keywords: CO2 laser
Drug screening
Epithelial-mesenchymal-transition
Microwell
Issue Date: 2011
Citation: Tu, T.-Y.,Sun, W.,Peng, W.K.,Wang, Z.,Huang, R.Y.J.,Matsudaira, P.T.,Thiery, J.-P.,Kamm, R.D. (2011). Rapid microwell prototyping, generation of 3D multicellular cancer aggregates, and emt drug screening. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 1 : 82-84. ScholarBank@NUS Repository.
Abstract: This work presents a microwell prototyping technique for generating multicellular cancer aggregates in suspension culture for epithelial- mesenchymal-transition (EMT) drug screening. Microwell and aggregate size and geometry were examined in PMMA, PDMS, polystyrene materials materials. Retrieved aggregates were further studied in terms of cell dispersion through drug screening, to identify the effective drug dosage for the inhibition of EMT. Two distinct cell phenotypic behaviors were discovered from Low-attachment-dish- and microwell-generated aggregates under different conditions. Future studies of the two types of aggregates may contribute to the understanding of cancer metastasis. Copyright © (2011) by the Chemical and Biological Microsystems Society.
Source Title: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
URI: http://scholarbank.nus.edu.sg/handle/10635/102231
ISBN: 9781618395955
Appears in Collections:Staff Publications

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