Please use this identifier to cite or link to this item: https://doi.org/10.1160/TH04-07-0435
Title: Two parallel prothrombin activator systems in Australian rough-scaled snake, Tropidechis carinatus. Structural comparison of venom prothrombin activator with blood coagulation factor X
Authors: Abu Reza, Md.
Swarup, S. 
Manjunatha Kini, R. 
Keywords: Factor X
Haemostasis
Prothrombin activation
Snake venom
Issue Date: Jan-2005
Source: Abu Reza, Md., Swarup, S., Manjunatha Kini, R. (2005-01). Two parallel prothrombin activator systems in Australian rough-scaled snake, Tropidechis carinatus. Structural comparison of venom prothrombin activator with blood coagulation factor X. Thrombosis and Haemostasis 93 (1) : 40-47. ScholarBank@NUS Repository. https://doi.org/10.1160/TH04-07-0435
Abstract: It is uncommon for similar pathways/systems to be involved in highly divergent functions within single organisms. Earlier, we have shown that trocarin D, a venom prothrombin activator, from the Australian rough-scaled snake Tropidechis carinatus, is structurally and functionally similar to the blood coagulation factor Xa (FXa). The presence of a haemostatic system in these snakes implies that they have two parallel prothrombin activating systems: one in the plasma, that participates in the life saving process of blood clotting and the other in their venom, where it acts as a toxin. Here, we report the complete cDNA sequence encoding the blood coagulation factor X (FX) from the liver of T carinatus. Deduced T. carinatus FX sequence shows ∼80% identity with trocarin D but ∼50% identity with the mammalian FX. Our present study confirms the presence of two separate genes - one each for FX and trocarin D, that code for similar proteins in T carinatus snake. These two genes have different expression sites and divergent uses suggesting that snake venom prothrombin activators have probably evolved by the duplication of the liver FX gene and subsequently marked for tissue-specific expression in the venom gland. © 2005 Schattauer GmbH, Stuttgart.
Source Title: Thrombosis and Haemostasis
URI: http://scholarbank.nus.edu.sg/handle/10635/102100
ISSN: 03406245
DOI: 10.1160/TH04-07-0435
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

13
checked on Apr 3, 2018

WEB OF SCIENCETM
Citations

7
checked on Apr 3, 2018

Page view(s)

32
checked on Mar 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.