Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/102000
Title: The role of cationic amino acid residues in the lethal activity of stonustoxin from stonefish (Synanceja horrida) venom
Authors: Khoo, H.-E.
Chen, D. 
Yuen, R.
Issue Date: Mar-1998
Source: Khoo, H.-E.,Chen, D.,Yuen, R. (1998-03). The role of cationic amino acid residues in the lethal activity of stonustoxin from stonefish (Synanceja horrida) venom. Biochemistry and Molecular Biology International 44 (3) : 643-646. ScholarBank@NUS Repository.
Abstract: Stonustoxin (SNTX) is a two subunit pore-forming cytolytic protein purified from the venom of the stonefish (Synanceja horrida). SNTX also possesses lethal activity. Since cationic residues contribute significantly to the cytolytic activity of several pore-forming toxins, we examined the role of lysine and arginine residues in the lethal activity of SNTX. SNTX lost its lethal activity when the positively-charged side chains of lysine residues were converted to negatively-charged side chains upon succinylation. When the arginine residues were modified using 2,3-butanedione, SNTX also lost its lethal activity. However, the domains for cytolytic and lethal activity may not necessarily be the same.
Source Title: Biochemistry and Molecular Biology International
URI: http://scholarbank.nus.edu.sg/handle/10635/102000
ISSN: 10399712
Appears in Collections:Staff Publications

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